Compartment Subtype Cluster Gene Comments Cardiomyocytes AtrialCardiomyocytes AtrialCardiomyocytesLeft "TNNT2,ACTN2,LDB3,CSRP3,SMPX,KCNMB2,PCDH7,RYR3,PANCR,MBP,NAV3,PITX2,NPTN,NPPA,MYL7,MYL4,MYH6,PPKAG2" "Genes NPPA,MYL7,MYL4,MYH6,PPKAG2 are from Kanemaru et al" Cardiomyocytes AtrialCardiomyocytes AtrialCardiomyocytesRight "TNNT2,ACTN2,LDB3,CSRP3,SMPX,NTM,ROR1,KIF26B,PLC1,ANGPT1,BRINP3,BMP10,NPTN,NPPA,MYL7,MYL4,MYH6,PPKAG2" "Genes NPPA,MYL7,MYL4,MYH6,PPKAG2 are from Kanemaru et al" Cardiomyocytes AtrialCardiomyocytes AtrialCardiomyocytesCycling "TNNT2,ACTN2,LDB3,CSRP3,SMPX,NTM,NPTN,NPPA,MYL7,MYL4,MYH6,PPKAG2" "Genes NPPA,MYL7,MYL4,MYH6,PPKAG2 are from Kanemaru et al" Cardiomyocytes VentricularCardiomyocytes VentricularCardiomyocytesLeftCompact "TNNT2,ACTN2,LDB3,CSRP3,SMPX,SLC1A3,ADGRL2,MGAT4C,CDH13,CRIM1,RABGAP1L,CPVL,SYNDIG1,TBX20,KCNQ5,HEY2,LRMDA,MYH7,MYL2,FHL2,RYR2,TTN,LDB3" "Genes MYH7,MYL2,FHL2,RYR2,TTN,LDB3 are from Kanemaru et al" Cardiomyocytes VentricularCardiomyocytes VentricularCardiomyocytesRightCompact "TNNT2,ACTN2,LDB3,CSRP3,SMPX,ANKRD1,MYL2,PRRX1,GPNMB,ZNF385D,RABGAP1L,CPVL,SYNDIG1,CYP2J2,CNN1,NPPB,XIRP2,MYH7,MYL2,FHL2,RYR2,TTN,LDB3" "Genes MYH7,MYL2,FHL2,RYR2,TTN,LDB3 are from Kanemaru et al" Cardiomyocytes VentricularCardiomyocytes VentricularCardiomyocytesLeftTrabeculated "TNNT2,ACTN2,LDB3,CSRP3,SMPX,SLC1A3,ADGRL2,MGAT4C,CDH13,CRIM1,ADCY5,SEMA5A,ADAMTSL1,SGCD,MYOM2,SPOCK1,SLIT3,BRINP3,CSMD1,CRNDE,OPCML,MYH7,MYL2,FHL2,RYR2,TTN,LDB3" "Genes MYH7,MYL2,FHL2,RYR2,TTN,LDB3 are from Kanemaru et al" Cardiomyocytes VentricularCardiomyocytes VentricularCardiomyocytesRightTrabeculated "TNNT2,ACTN2,LDB3,CSRP3,SMPX,ANKRD1,MYL2,PRRX1,GPNMB,ZNF385D,ADCY5,SEMA5A,ADAMTSL1,SGCD,MYOM2,SPOCK1,SLIT3,NCALD,ENOX1,KCNIP4,SORCS3,MYH7,MYL2,FHL2,RYR2,TTN,LDB3" "Genes MYH7,MYL2,FHL2,RYR2,TTN,LDB3 are from Kanemaru et al" Cardiomyocytes VentricularCardiomyocytes VentricularCardiomyocytesCycling "TNNT2,ACTN2,LDB3,CSRP3,SMPX,MYH7,MYL2,FHL2,RYR2,TTN,LDB3" "Genes MYH7,MYL2,FHL2,RYR2,TTN,LDB3 are from Kanemaru et al" Cardiomyocytes CardiacConductionSystem SinoatrialNodePacemakerCells "TNNT2,ACTN2,LDB3,CSRP3,SMPX,MYH6,CACNA1D,KCNJ3,NR2F2,NRXN1,CAMK1D,HCN1,TBX3,SHOX2,PDE1A,TENM4,MYH11,TBX18,NPTN,HCN4" HCN4 is from Kanemaru et al Cardiomyocytes CardiacConductionSystem AtrioventricularNodePackemakerCells "TNNT2,ACTN2,LDB3,CSRP3,SMPX,MYH6,CACNA1D,KCNJ3,NR2F2,NRXN1,CAMK1D,HCN1,TBX3,GREB1L,GNG11,NRXN3,RSPO3,ZNF536,NPTN,HCN4" HCN4 is from Kanemaru et al Cardiomyocytes CardiacConductionSystem VentricularConductionSystemProximal "TNNT2,ACTN2,LDB3,CSRP3,SMPX,MYH7,MYL2,NAV1,ADAMTSL1,GJA1,GCNT2,LPL,PCDH7,PRDM16,NIBAN1,PHACTR1,FGF18" Cardiomyocytes CardiacConductionSystem VentricularConductionSystemDistal "TNNT2,ACTN2,LDB3,CSRP3,SMPX,MYH7,MYL2,NAV1,ADAMTSL1,GJA1,GCNT2,LPL,OPCML,NTN1,IRX3,IRX2,DGKG" Mesenchymal Fibroblasts GreatVesselAdventitialFibroblasts "FBLN1,LRRC17,NLGN1,FOS,PCDH7,COLEC12,FBN1,DCN,SFRP2,ROR1,TSHZ2,MEIS1,PIEZO2" Mesenchymal Fibroblasts CoronaryVesselAdventitialFibroblasts "COL6A3,FBLN1,MFAP4,LRRC17,TCF21,FN1,FBN1,DCN,PDGFRA,TCF21,MOXD1,FNDC1,FBLN5,DES,CEMIP,SLIT3,TBX20,SCN7A,FREM1,TCF21,GATA4" Mesenchymal Fibroblasts MyocardialInterstitialFibroblasts "COL6A3,MFAP4,LRRC17,TCF21,FN1,FBN1,DCN,PDGFRA,TCF21,EPHA3,SCN7A,COL15A1,ROBO2,CD34,COL25A1,MYRIP,NRG1" Mesenchymal Fibroblasts SubEpicardialFibroblasts "COL6A3,FBLN1,LRRC17,TCF21,FN1,FBN1,DCN,PDGFRA,SLIT3,MIR100HG,FLRT2,BNC2,CASC15,TSHZ2,PRRX1,SFRP1,BRINP3,EPHA3" Mesenchymal Fibroblasts Myofibroblasts "COL6A3,LRRC17,TCF21,FN1,FBN1,DCN,TNC,TCF21,CASC15,EPHA3,IGFBP7,SEMA5A,APOE,ITGA1,HES4,NOTCH3,PLA2G5,MCAM" Mesenchymal Fibroblasts LymphNodeFibroblasticReticularCells COL6A3 Mesenchymal Fibroblasts ValveInterstitialCells "MFAP4,COL9A2,PTN,ID4,PRRX1,BAMBI,INHBA,CLU,TWIST1,COL9A3,COL9A2,IGF1,RSPO3,MMP23B,SCX,COL9A1" Mesenchymal MuralCells GreatVesselSmoothMuscleCells "FBLN1,MFAP4,LRRC17,PTGER3,PDE3A,NLGN1,PCDH7,COLEC12,FN1,FBN1,ELN,FBLN5,THSD4,SFRP1,PRDM6,ERBB4" Mesenchymal MuralCells CoronarySmoothMuscleCells "COL6A3,EDNRA,EDNRB,FOS,FN1,AGRN,NR2F2,TFPI,TBX2,ENPEP,COL18A1" Mesenchymal MuralCells DuctusArteriosusSmoothMuscleCells "MFAP4,ROBO2,DCLK2,PDE1C,TAFA1,CSMD1,CHRM2,PTGER4,PDE3A,PDE4D,PDE5A,FOS,FOSB,PCDH7,FN1,ELN,FBLN5,TNC" Mesenchymal MuralCells CoronaryPericytes "COL6A3,EDNRA,EDNRB,FN1,AGRN" Mesenchymal PericardialCells PericardialCellsIntermediate "COL6A3,FBLN1,PCOLCE,WT1,COL6A3,COL12A1,POSTN,VCAN,COL16A1,GPC3,ITM2A,TSHZ2,AUTS2,PID1,CD9,CD63,CD81,COL1A2" Mesenchymal PericardialCells PericardialCellsFibrous "COL6A3,FBLN1,PCOLCE,COL6A3,COL12A1,POSTN,VCAN,COL16A1,GPC3,SPARCL1,ITM2A,SERPINF1,CD9,CD63,CD81,COL1A1,COL1A2,COL3A1" Mesenchymal PericardialCells PericardialCellsParietal "COL6A3,WT1,COL6A3,COL12A1,POSTN,VCAN,COL16A1,COL12A1,MEG3,TSHZ2,AUTS2,SETBP1,PID1,PDZRN3" Endothelium BloodVesselEndothelialCells GreatVesselArterialEndothelialCells "ECSCR,CDH5,PTPRB,TIE1,NLGN1,FOS,FOSB,COLEC12,FN1,ELN,FLN5,HSPG2,HMCN1,COL3A1,MEIS2,PLXNA4,NRG3" Endothelium BloodVesselEndothelialCells GreatVesselVenousEndothelialCells "ECSCR,EMCN,CDH5,PTPRB,TIE1,PCDH7,COLEC12,FBN1,HSPG2,HMCN1,COL3A1,MEIS2,PLXNA4,NRG3" Endothelium BloodVesselEndothelialCells CoronaryArterialEndothelialCells "ECSCR,CDH5,PTPRB,TIE1,FN1,FBN1,ELN,FBLN5,HSPG2,AGRN,A2M,COL4A1,COL4A2,H19,ADGRL4" Endothelium BloodVesselEndothelialCells CoronaryVenousEndothelialCells "ECSCR,EMCN,CDH5,PTPRB,TIE1,FBN1,HSPG2,A2M,COL4A1,COL4A2,H19,ADGRL4" Endothelium BloodVesselEndothelialCells CoronaryCapillaryEndothelialCells "ECSCR,EMCN,CDH5,PTPRB,TIE1,HSPG2,AGRN,A2M,COL4A1,COL4A2,H19,ADGRL4" Endothelium EndocardialCells EndocardialCells "ECSCR,EMCN,CDH5,TIE1,PCDH7,ADGRG6,NPR3,SMOC1,POSTN" Endothelium EndocardialCells EndocardialCushionCells "ECSCR,EMCN,CDH5,TIE1,TMEM132D,TSPAN8,HAS2,PROX1,COL26A1,BMP4,GJA4,TMEM132D,TSPAN8,CNR1,MSX1,APCDD1,NFATC1,BAMBI,POSTN" Endothelium EndocardialCells ValveEndothelialCells "ECSCR,EMCN,CDH5,PTPRB,TIE1,APCDD1,HAPLN1,KLF2,FXYD5,LTC4S,CCL21,NFATC1,NRGN,DKK2,KCNJ2,SULF1,GJA1,KISS1" Endothelium LymphaticEndothelialCells LymphaticEndothelialCells "ECSCR,CDH5,TIE1,CCL21,PECAM1,PROX1,CD36,MPP7,STAB2,PARD6G,DOCK5,LYVE1,STON2" Epicardium EpicardialCells MesothelialEpicardialCells "BNC1,MYRF,ITLN1,UPK3B,MSLN,WT1,TPM1,ALDH1A2,EZR,CFI,KRT8,KRT18,BNC1,MSLN,HAS1,PRG4,SBSPON,ITLN1,TBX18" Epicardium EpicardialCells EpicardiumDerivedCells "BNC1,MYRF,ITLN1,UPK3B,MSLN,WT1,TPM1,ALDH1A2,EZR,CFI,KRT8,KRT18,BNC1,MSLN,HAS1,PRG4,KDR,FLRT3,CPB1,VEGFC" Neural Neurons NeuronPrecursors "PHOX2B,NRXN1,SYT1,CD24,PCLO,ASCL1,NELL2,BNC2,DLL3,FNDC5" Neural Neurons ChromaffinCells "NRXN1,SYT1,PCSK1N,CD24,EML5,PCLO,DLK1,EPAS1,KCNJ6,CCSER1,INSM1,VEGFA,NDUFA4L2,ADM,SLC18A2,FZD5" Neural Neurons SympatheticNeurons "PHOX2B,SYT1,PCSK1N,CD24,EML5,PCLO,PHOX2A,STMN2,GATA3,ISL1,RGS5,DBH,VSTM2L,RTN1" Neural Neurons ParasympatheticNeurons "PHOX2B,CDH6,NRXN1,CNTN2,SYT1,PCSK1N,CD24,EML5,PCLO,PHOX2A,STMN2,GATA3,ISL1,RTN1,ELAVL2,MAPT,PRPH,MTUS1,CADPS,NEFL,PLPP4,CELF4,SST,PRUNE2,SV2C,PGM2L1,TMEM59L,SLC5A7,TENM2" Neural Glia SchwannCellPrecursors "PHOX2B,SLC35F1,ZNF536,CDH6,NRXN1,PTPRZ1,CDH19,ERBB3,MEF2C,CDH6,SOX5,LAMA4,COL5A2,MPZ,PLS3,SLITRK6,IL1RAPL2,GFRA1,PTN,PRKG1,COL20A1,IL1RAP" Neural Glia SchwannCells "SLC35F1,ZNF536,CDH6,NRXN1,PTPRZ1,CDH19,ERBB3,MEF2C,CDH6,SOX5,LAMA4,COL5A2,MPZ,LAMB1,COL4A1,OLFML2A,NR2F2,GASK1B,EGFL8,HSPG2,COL14A1,PLEKHA4,IGA6,SCN7A,LAMA2,ARHGAP15,NRXN3,SEMA3B,TGFBR3" Leukocytes MyeloidCells MonocytesMPOpos LCP1 Leukocytes MyeloidCells Monocytes "PTPRC,LCP1" Leukocytes MyeloidCells MonocyteDerivedCells "PTPRC,RUNX1,DOCK2,IKZF1,LCP1" Leukocytes MyeloidCells MacrophagesCX3CR1pos "PTPRC,RUNX1" Leukocytes MyeloidCells MacrophagesTIMD4pos "PTPRC,RUNX1,DOCK2,IKZF1,LCP1" Leukocytes MyeloidCells MacrophagesLYVE1pos "PTPRC,RUNX1,DOCK2" Leukocytes MyeloidCells MacrophagesATF3pos "PTPRC,RUNX1,DOCK2" Leukocytes MyeloidCells DendriticCellsType1 "PTPRC,RUNX1,DOCK2,IKZF1,LCP1" Leukocytes MyeloidCells DendriticCellsMature "RUNX1,DOCK2,IKZF1,LCP1" Leukocytes MyeloidCells PlasmocytoidDendriticCells "PTPRC,RUNX1,DOCK2,IKZF1,LCP1" Leukocytes MyeloidCells MastCells "RUNX1,DOCK2,IKZF1,LCP1" Leukocytes MyeloidCells Megakaryocytes RUNX1 Leukocytes LymphoidCells TCellsCD4pos "PTPRC,RUNX1,DOCK2,IKZF1,LCP1" Leukocytes LymphoidCells TCellsCD8pos "PTPRC,RUNX1,DOCK2,IKZF1,LCP1" Leukocytes LymphoidCells TregsCD4pos "PTPRC,RUNX1,DOCK2,IKZF1,LCP1" Leukocytes LymphoidCells ProBCells "RUNX1,IKZF1" Leukocytes LymphoidCells Bcells "PTPRC,RUNX1,DOCK2,IKZF1" Leukocytes LymphoidCells BcellsMS4A1pos "PTPRC,RUNX1,DOCK2,IKZF1,LCP1" Leukocytes LymphoidCells NaturalKillerCells "PTPRC,RUNX1,DOCK2,IKZF1,LCP1" Leukocytes LymphoidCells InnateLymphoidCells "PTPRC,IKZF1,LCP1"