#!/home/passala/miniconda3/envs/Genomealign/bin/perl

=head1 NAME

bp_taxonomy2tree - Building a taxonomic tree based on the full lineages of a set of species names

=head1 DESCRIPTION

This scripts looks up the provided species names in the NCBI Taxonomy database,
retrieves their full lineage and puts them in a Newick taxonomic tree displayed
on screen.

  bp_taxonomy2tree.pl -s Orangutan -s Gorilla -s Chimpanzee -s Human
  bp_taxonomy2tree.pl -s Orangutan -s Gorilla -s Chimpanzee -s "Homo Sapiens"

Can also provide -d to specify the directory to store index files in, -o to
specify the location of your NCBI nodes file, and -a for the NCBI names file.
Or the option -e to use the web-based Entrez taxonomy database if you do not
have the NCBI flatfiles installed.

This script requires that the bioperl-run pkg be also installed.

Providing the nodes.dmp and names.dmp files from the NCBI Taxonomy
dump (see Bio::DB::Taxonomy::flatfile for more info) is only necessary
on the first time running.  This will create the local indexes and may
take quite a long time.  However once created, these indexes will
allow fast access for species to taxon id OR taxon id to species name
lookups.

=head1 AUTHOR - Gabriel Valiente, reimplemented by Sendu Bala

Email valiente@lsi.upc.edu
Email bix@sendu.me.uk

=cut

use strict;
use warnings;
use Bio::DB::Taxonomy;
use Bio::TreeIO;
use Bio::Tree::Compatible;
use Getopt::Long;

my @species;
my $index_dir = "./db/";
my $nodesfile = "nodes.dmp";
my $namesfile = "names.dmp";
my $use_entrez = 0;

# the input to the script is an array of species names
GetOptions( 's|species=s'   => \@species,
            'd|dir:s'       => \$index_dir,
            'o|nodesfile:s' => \$nodesfile,
            'a|namesfile:s' => \$namesfile,
            'e|entrez'      => \$use_entrez,
            'h|help'        => sub { system('perldoc', $0); exit }, );

my $db = Bio::DB::Taxonomy->new( -source    => $use_entrez ? 'entrez' : 'flatfile',
                                 -directory => $index_dir,
                                 -nodesfile => $nodesfile,
                                 -namesfile => $namesfile );

# the full lineages of the species are merged into a single tree
my $tree;
for my $name (@species) {
  my $node = $db->get_taxon(-name => $name);
  if ($node) {
    if ($tree) {
      $tree->merge_lineage($node);
    }
    else {
      $tree = Bio::Tree::Tree->new(-node => $node);
    }
  }
  else {
    warn "no NCBI Taxonomy node for species ",$name,"\n";
  }
}

# simple paths are contracted by removing degree one nodes
$tree->contract_linear_paths;

# convert tree ids to their names for nice output with TreeIO
foreach my $node ($tree->get_nodes) {
  $node->id($node->node_name);
}

# the tree is output in Newick format
my $output = Bio::TreeIO->new(-format => 'newick');
$output->write_tree($tree);
$output->close;

1;